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دنیای داروها - تداخل دارویی اسپیرونولاکتون و یاسمین...
 
دنیای داروها
  چند وقت پیش خانمی که یاسمین رو به صورت OTC بی هیچ پرسش و پاسخی! از تکنسین داروخونه‌ی محل کارم دریافت کرده بود٬ شاکی به داروخونه مراجعه کرد٬ که بعد از چند روز مصرف این قرص دست و پاهام شل شد و ضعف جسمانی پیدا کردم و کارم به درمونگاه کشید و پزشک گفت که مشکل از این قرصه و ممکن بود مشکل جدی قلبی و ... واستون پیش بیاد و به خیر گذشته.
 تو ذهنم عوارض احتمالی یاسمین رو مرور ‌کردم و هرچی ‌گشتم به عارضه ضعف عضله و مشکل قلبی نرسیدم! تنها چیزی که به ذهنم رسید تداخلات دارویی و بیماری های همزمان احتمالی بود. در این مورد که ازش پرسیدم مسئله حل شد!

 مریض همزمان برای درمان آکنه اسپیرونولاکتون هم مصرف می‌کرده و این علائمی که پیدا کرده بود ناشی از هایپرکالمی ایجاد شده به خاطر مصرف همزمان این دو دارو بود ... (موردی که توسط پزشک معالجش هم مطرح شده بود.)

اگرچه یاسمین به نسبت بقیه‌ی کنتراسپتیوهای خوراکی کم‌عارضه‌تر هست و در بسیاری از موارد بهترین انتخاب٬ اما به خاطر ترکیب پروژستینی متفاوتی که در ساختارش داره در خیلی از موارد منع مصرفش وجود داره. هر قرص یاسمین حاوی 30 میکروگرم اتینیل‌استرادیول و 3میلی گرم دروسپایرنون هست.

  ٬Drospirenone پروژستین موجود در این قرص٬ با جزء پروژستینی موجود در کنتراسپتوهای معمول٬ (مثل LD و HD) یعنی لوونورژسترل متفاوته و دارای خاصیت آنتی‌مینرالوکورتیکوئیدی هست و در نتیجه می‌تونه باعث ایجاد هایپرکالمی بشه. در واقع Drospirenone آنالوگ اسپرونولاکتون محسوب میشه و هر ۳ میلی‌گرم اون معادل ۲۵ میلی‌گرم اسپیرونولاکتون هست٬ یعنی هر قرص یاسمین معادل یه قرص اسپیرونولاکتون اثرات هایپرکالمیک میتونه ایجاد کنه!


  به همین خاطر مصرفش در کسانی که:

 نارسایی کبدی٬ کلیوی و آدرنال دارند

و همین‌طور افراد مصرف کننده داروهایی که موجب هایپرکالمی می‌شوند٬ مثل دیورتیک‌های نگهدارنده‌ی پتاسیم٬ NSAIDs (مصرف مزمن‌شون)٬ هپارین٬ ACEIs و آنتاگونیست‌های گیرنده‌ آنژیوتانسین II و ...

باید با مشورت پزشک معالج انجام بشه.

دانستنیهای داروخانه




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جمعه 24 شهریور 1396 01:18 ق.ظ
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شنبه 4 شهریور 1396 11:34 ق.ظ
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دوشنبه 16 مرداد 1396 07:34 ق.ظ
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شنبه 7 مرداد 1396 07:50 ب.ظ
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جمعه 16 تیر 1396 06:19 ب.ظ
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یکشنبه 21 خرداد 1396 10:52 ق.ظ
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یکشنبه 31 اردیبهشت 1396 08:14 ب.ظ
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سه شنبه 26 اردیبهشت 1396 05:31 ق.ظ
قلب از خود نوشتن در حالی که ظاهر شدن مناسب در آیا نه نشستن خوب با من پس از برخی از زمان.
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که شما که می توانید انجام
من را قطعا بود در گم.
سه شنبه 26 اردیبهشت 1396 03:06 ق.ظ
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دوشنبه 25 اردیبهشت 1396 03:57 ب.ظ
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پنجشنبه 7 اردیبهشت 1396 08:24 ق.ظ
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شنبه 2 اردیبهشت 1396 05:53 ق.ظ
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چهارشنبه 23 فروردین 1396 12:56 ق.ظ
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پنجشنبه 17 فروردین 1396 12:34 ق.ظ
سلام، من براى درمان جوشم باید اسپیرونولاكتون و قرص جلوگیرى از باردارى مصرف كنم، اما متأسفانه هیچ كدوم ازین قرصا بجز یاز به من نمى سازه و حالمو به شدت بد مى كنه، كلایرت و دیان رو امتحان كردم، نمى دونم باید چیكار كنم تا حالا ٣ تا دكتر رفتم همه گفتن یاز رو جایگزین كنم ولى قرصى رو پیدا نكردم كه حالمو بد نكنه، از طرفى اسپیرونولاكتون رو هم كه قطع مى كنم جوشهام بر مى گردن!
سه شنبه 15 فروردین 1396 10:48 ق.ظ
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دوشنبه 14 فروردین 1396 09:08 ب.ظ
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یکشنبه 13 فروردین 1396 02:00 ب.ظ
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پنجشنبه 10 فروردین 1396 05:53 ب.ظ
Excellent blog here! Also your website loads up fast!
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